Prolonged use may lead to liver impairment and may cause hemolytic anemia.Īnimals sensitive to other sulfonamides such as furosemide may be sensitive to silver sulfadiazine. Urinalyses may be required prior to and periodically during treatment to detect crystalluria and/or urinary calculi formation in horses with impaired renal function on long-term or high-dose therapy. Monitoring of blood count and serum sulfadiazine concentration may be necessary in cases of treatment of extensive burns. Use of silver sulfadiazine may create areas of dead skin, a burning sensation, red and raised rash on the body, and skin discoloration. Follow your veterinarian's instructions regarding use of this, or any medication. Calculator is for educational purposes only.Always check the label and literature provided with the medication about the form and concentration and DO NOT USE the calculator if the information differs. This medication may be available in forms and concentrations not noted in the above table.Even if your equine appears to feel better, the entire treatment plan should be completed to prevent relapse. Be certain to complete the prescription unless specifically directed by your veterinarian. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian).Federal law restricts this drug to use by or on the order of a licensed veterinarian.Dosage and Administration Silver Sulfadiazine The American Journal of Veterinary research reports that it may be a therapeutic option in the treatment of equine keratomycosis. Ongoing research also shows that silver sulfadiazine may be an effective treatment against common corneal fungal infections in horses. It is also helpful on other shallow, large area wounds such as abrasions. It prevents the growth of a wide array of bacteria, as well as yeast, on damaged skin. Silver sulfadiazine is used primarily as a topical burn cream on second and third degree burns in horses. Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. It acts on the cell membrane and cell wall. It is effective against many gram-positive and gram-negative organisms. systemic adverse effects related to sulfonamides (haematological, renal, cutaneous disorders, etc.) when applied to a large surface area, mucous membranes or prolonged use.Silver sulfadiazine is a broad-spectrum, synthetic antibacterial agent with a chemical structure that includes sulfur and nitrogen atoms.skin reactions, grey skin discoloration, skin photosensitivity rarely: allergic reactions, sometimes severe (Lyell’s and Stevens-Johnson syndromes).Use with caution in children under 2 years (risk of systemic absorption) in patients with severe renal or hepatic impairment. Do not apply other topical treatments to wounds where silver sulfadiazine is applied.Do not use in patients with allergy to sulfonamides in children under 2 months.Until wound has healed or until skin graft, when required.Ĭontra-indications, adverse effects, precautions.Child 2 months and over and adult: clean the wound then apply a 3 to 5 mm layer of silver sulfadiazine cream to the wound once daily and cover with sterile compresses.Prophylaxis and treatment of infections of in severe burns.
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